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Dr. Melanie Martin

Physics


Melanie Martin

Ph. D. (Yale, 2000)

Director, Magnetic Resonance Microscopy Centre

Professor, Physics, University of Winnipeg

Past-Chair, Division of Physics in Medicine and Biology, Canadian Association of Physicists

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Phone (office): (204) 786-9442
Phone (lab): (204) 789-3472
Fax: (204) 774-4134
Office: 3L21
E-Mail: m.martin@uwinnipeg.ca
Web Site:  mri.uwinnipeg.ca

COURSES (2016-2017):

  • PHYS-2503 - Medical Imaging
  • PHYS-3301 - Quantum Mechanics I (Fall Term)

Physics Demo Links (pages will open in new windows):


RESEARCH INTERESTS:

  • As a physicist specializing in magnetic resonance imaging (MRI), I am developing a non-invasive, empirical method to diagnose Alzheimer's disease, Multiple Sclerosis, and other central nervous systems disorders as early as possible. I am also using MRI to follow the effectiveness of treatment regimes over the course of time.
    Research Web Page:  mri.uwinnipeg.ca


RECENT PUBLICATIONS and CONFERENCE PRESENTATIONS:

  • Herrera SL, Mercredi ME, Vincent TJ, Buist R, Martin M, Using oscillating gradient spin-echo sequences to infer micron-sized bead and pore radii. ISMRM 2015, 3027.
  • Herrera SL, Whittaker H, Zhu S, Palmer VL, Buist R, Li X, Thiessen JD, Martin M, Comparison of Relaxation, Magnetization Transfer, and Diffusion Tensor Measurements in the Hippocampal Formation between APP, PS1, and Control Mice. ISMRM 2015, 2227.
  • Palmer VL, Herrera SL, Thiessen JD, Zhu S, Buist R, Li XM, Del Bigio MR, Martin M, Understanding the interplay different MRI methods have as white matter changes longitudinally in the cuprizone mouse Model. ISMRM 2015, 3574.
  • Martin M, Palmer VL, Herrera SL, Zhu S, Buist R, Li XM, Del Bigio MR, Thiessen JD, Correlating quantitative MR changes with pathological changes in the white matter of the cuprizone mouse model of demyelination Canadian Association of Physicist Annual Congress, Edmonton, AB2015
  • Herrera SL, Palmer VL, Whittaker H, Cardigan Smith B, Kim A, Schellenberg AE, Thiessen JD, Buist R, Del Bigio MR, Martin MDamage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein – Experimental Autoimmune Encephalomyelitis Mice, Magnetic Resonance Insights 2014:7 23-31.
  • Hayes K, Buist R, Vincent TJ, Thiessen JD, Zhang Y, Zhang H, Wang J, Summers AR, Kong J, Li XM, Martin M, Comparison of Manual and Semiautomated Segmentation Methods to Evaluate Hippocampus Volume in APP and PS1 Transgenic Mice obtained via in-vivo Magnetic Resonance Imaging, Journal of Neuroscience Methods, 221, 2014.
  • Herrera SL, Vincent TJ, Mercredi ME, Buist R, Bidinosti CP, Martin M, Inferring Axon Diameter Sizes using Monte Carlo Simulations and Oscillating Gradient Spin Echo Sequences. ISMRM 2014.
  • Palmer VP, Herrera SL, Thiessen JD, Zhu S, Buist R, Li XM, Martin M. Understanding white matter pathology through correlating longitudinal and quantitative MRI metrics weekly in the cuprizone mouse model of demyelination. ISMRM 2014.
  • Martin M, Vincent TJ, Mercredi ME, Herrera SL, Buist R, Bidinosti CP, “Inferring sub-micron sizes using oscillating gradient diffusion weighted magnetic resonance imaging.” Canadian Association of Physicist Annual Congress, Sudbury, ON 2014, Invited talk.
  • Kastyak-Ibrahim MZ, Di Curzio DL, Buist R, Herrera SL, Albensi BC, Del Bigio MR, Martin M, Neurofibrillary tangles and plaques are not accompanied by white matter pathology in aged triple transgenic-Alzheimer disease mice, Magnetic Resonance Imaging, 31 (2013) 1515-1521.
  • Herrera SL, Vincent TJ, Buist R, Bidinosti CP, Martin M.  Using Oscillating Gradient Spin Echo Sequences to Probe Smaller Restriction Sizes. (2013). International Society for Magnetic Resonance in Medicine (ISMRM) Diffusion as a Probe of Neural Tissue Microstructure, Podstrana, Croatia.
  • Thiessen JD, Hayes K, Martin M, Relaxation, Magnetization Transfer, and Diffusion Tensor Measurements in the Hippocampus of APP and PS1 Transgenic Mice, ISMRM 2013.
  • Herrera SL, Vincent TJ, Thiessen JD, Buist R, Martin M, Distinguishing small pore sizes using oscillating gradient spin echo sequences, ISMRM 2013.
  • Thiessen JD, Zhang Y, Zhang H, Wang L, Buist R, Del Bigio MR, Kong J, Li, XM, Martin M. Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination, NMR in Biomedicine, 2013, 26; 1562-1581.
  • Martin MMeasuring Restriction Sizes Using Diffusion Weighted Magnetic Resonance Imaging: A Review. Magnetic Resonance Insights, 2013:6 59-64.
  • Thiessen JD, Vincent TJ, Herrera SL, Martin MDiffusion Tensor Metric Measurements as a Function of Diffusion-Time in Rat Central Nervous System, Magnetic Resonance Insights, 2012:5 37-47.
  • Soylu H, Zhang D, Buist R, Martin M, Albensi BC, Parkinson FE, Intracortical injection of endothelin-1 induces cortical infarcts in mice:  effect of neuronal expression of an adenosine transporter, Experimental & Translational Stroke Medicine, 2012, 4:4.
  • Hayes K, Buist R, Vincent T, Zhang Y, Thiessen JD, Zhang H, Kong J, Li XM, Martin M, Development of an In-Vivo Magnetic Resonance Imaging Method to Evaluate Hippocampus Volume in APP and PS1 Transgenic Mice, Alzheimer’s Association International Conference, Vancouver, 2012.
  • Thiessen JD, Zhang Y, Zhang H, Wang L, Buist R, Kong J, Li X-M, and Martin M. Correlating longitudinal and quantitative MRI metrics elucidates white matter changes in the cuprizone mouse model of demyelination. International Society for Magnetic Resonance in Medicine (ISMRM) Annual Meeting, Montreal 2011;4187.
  • Vincent TJ, Thiessen JD, Kurjewicz LM, Germscheid SL, Turner AJ, Zhilkin P, Alexander ME, Martin MLongitudinal Brain Size Measurements in APP/PS1 Transgenic Mice, Magnetic Resonance Insights, 2010:4 19–26.
  • Thiessen JD, Glazner KAC, Nafez S, Schellenberg AE, Buist R, Martin M, and Albensi BC. Histochemical visualization and diffusion MRI at 7 Tesla in the TgCRND8 transgenic model of Alzheimer's disease. Brain Structure and Function (2010), 215:29-36.
  • Odero GL, Oikawa K, Glazner KAC, Grossman D, Thiessen JD, Motnenko A, Ge N, Martin M, Glazner GW, Schapansky J, Albensi BC. Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease. Neuroscience 169 (2010), 532-543.
  • Thiessen JD, Zhang Y, Zhang H, Wang L, Buist R, Kong J, Li X-M, and Martin M. Monitoring Demyelination in a Cuprizone Mouse Model with Longitudinal and Quantitative MRI Measurements. International Society for Magnetic Resonance in Medicine (ISMRM) 2010 Annual Meeting, Stockholm, 4512.
  • MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs RE, Johnson GA, Toga AW, Voskuhl RR, Purkinje cell loss in experimental autoimmune encephalomyelitis, Neuroimage 48 (2009), 637-651.